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Ask what symptoms should be evaluated first, whether labs or stool testing are appropriate, what the research actually supports, what is still unknown, how safety would be monitored, and how progress would be measured

Gille D, Schmid A

10.1038/nrm2312 Nat

Ecole Polytechnique Federale de Lausanne (EPFL) and Nestle carried out the study

Sleep improvements typically appear within 2-4 weeks, while body composition and performance changes develop over 2-3 months, with continued optimization through 6 months

This review reflects the potential importance of the vitamin B12 assay as an early diagnostic marker of these diseases