Second, we excluded patients with prior suicidal ideation or suicide attempts to reduce confounding, but this prevented us from evaluating whether tirzepatide could reduce suicidality in that high-risk subset
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Although systemic administration offers the advantage of non-invasive delivery, the low bioavailability of CUR due to its poor solubility and rapid metabolism poses challenges
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Santini SE, Basini G, Bussolati S, Grasseli F
This dual action often produces stronger appetite suppression and blood sugar control from the start, though nausea rates are similar
