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[6] [7] The corneal branch is notable only because it is the one that actually reached human trials and it did so as a defined topical formulation of the full protein, not as a systemic fragment

M.WangY.Mejia-SantanaH.HarrisJ.LouisE

PMID 9610496

While both can cause discomfort and concern, understanding their differences is crucial for effective treatment and management

These quality-control measures help support consistent laboratory performance across experimental protocols

Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]