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Also, for the CC category, plasma membrane (GO:0005886, 105 methylated genes), membrane (GO:0016020, 104 methylated genes), and cytosol (GO:0005829, 81 methylated genes) GO terms demonstrated significant enrichment (Supplementary Figure S2 and File S6)

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However, the most important takeaway is that formulation matters more than quantity

Metabolism , 45 (12), 15391546