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2,3 Additionally, cancer cells are prone to develop resistance to chemotherapeutic drugs resulting from drug inactivation or efflux, target protein alteration, DNA damage repair, and signaling cascade alteration, which greatly limits the efficacy of such drugs

doi: 10.1038/s41430-019-0394-0 322 MaroofHHassanZMMobarezAMMohamadabadiMA

Cases where CF mothers received CFTR modulators during pregnancy have shown resolution of MRI in their infants 116,117 , suggesting a preventative effect on fetal intestinal pathologies 118

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