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These results fall short of demonstrating a dominant role for the sculpting by LOH of non-synonymous mutations or neoantigens, but leave open the possibility that selection for deletion of specific mutations may account for large-scale LOH in some patients

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Whilst we found that melatonin did not affect the concentration of G6P ( Figure 5H ), it did seem to greatly reduce the amount of F6P present in our cell samples, indicating potentially that the key disruption to this pathway occurred at the step where G6P is converted to F6P ( Figure 5E )

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