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Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: evidence for sexual dimorphism

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If the main drivers are stress physiology, under-eating, gut inflammation, thyroid dysfunction, nutrient deficiencies, sleep disruption, or adrenal dysregulation, appetite suppression is not the best first move and may do harm

For example, first using a phage cocktail to precisely clear identified key pathogens (such as ethanol-producing Klebsiella pneumoniae ), followed by supplementing combinations of screened probiotic strains capable of producing specific beneficial metabolites (such as butyrate and indole-propionic acid) to fill the ecological niche and restore function