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Tetrahedron Lett 45:5677

High-dose intravenous protocols (up to 50 mg/kg daily, ~3,500 mg for a 70 kg person) have been used safely in patients with metabolic disorders [8] , indicating a wide therapeutic margin

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Possible serious adverse reactions listed in the prescribing information for these medications include pancreatitis, gallbladder disease, hypoglycemia, kidney problems linked to dehydration, and severe gastrointestinal reactions

[136] reported that N-CQDs significantly reduced fungal counts in both in vitro assays and an in vivo rat model of mucormycosis, with antifungal effects attributed to ROS generation, disruption of fungal cell wall integrity, and increased membrane permeability [136]

Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]