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Collectively, these results suggested that ferroptosis inhibition may mitigate IL-1-induced increase in vascular permeability in ECs
Open Microbiol
Biochimica et Biophysica Acta (BBA)-Bioenerg 1757:13711387 Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G et al (2022) Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway
Tanaka M, Trk N, Tth F, Szab , Vcsei L
This is achieved through upregulation of death receptors DR3, DR5, FasL, and TNF-R1 on the cell membrane, leading to increased caspase-8 expression
These findings are of relevance and suggest that the baseline perturbations in airway GSH and GSSG homeostasis in subjects with asthma may increase the risk of airway injury from secondary insults such as antigen exposure
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