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To increase the chance of spotting melanoma early, recommend: A self-skin examination monthly A patient noticing a significant change in a mole or a new lesion should show this to their doctor or dermatologist Regular skin examinations in patients with many naevi, atypical naevi, or who have had a previous skin cancer Total body photography and digital dermatoscopic imaging (mole mapping) for patients at high risk of melanoma, especially if they have many melanocytic naevi

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Patient Input CADTH received 1 patient group submission from the International Coalition of Organizations Supporting Endocrine Patients (ICOSEP)

The liver tissues were digested with 5% KOH at 37 C overnight and washed twice with PBS