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Supports nitric oxide and blood vessel formation to improve nutrient delivery

The peptide's pro-angiogenic and pro-mitogenic mechanisms that make it attractive for tissue repair are the same mechanisms that generate concern about tumor biology, aberrant vascular remodeling, and endocrine interference

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[3] [4] This metabolic involvement has led some to speculate about a connection between B12 and energy or fat metabolism a claim that warrants careful scrutiny

They were seeded onto 6-well cell culture plates and transiently transfected with different GLP-2R constructs using Lipofectamine 2000 transfection reagent (Invitrogen, Carlsbad, CA, USA)