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It has since been used in clinical settings for fatigue, muscle spasm, upper respiratory conditions, and immune support

Phase 3: Titrate Up (Only If Needed) Goal: Increase dose gradually if Phase 2 is not producing adequate results

doi:10.1111/dom.14944 [DOI] [PubMed] [Google Scholar] 19.Jones KL, Huynh LQ, Hatzinikolas S, et al

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502,503 Of note, ITI-214, a specific PDE1 inhibitor, has been well-tolerated by humans and a phase 2 clinical trial for heart failure has been completed