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When Zepbound is covered, prior authorization is usually required, and the patient may need to meet clinical requirements such as a BMI of 30 or more or a BMI of 27 or more with a comorbid condition like hypertension or Type 2 diabetes, and documented weight management efforts like a low-calorie diet and increased physical activity

doi: 10.1016/j.biopsych.2026.05.002 10.1016/j.biopsych.2026.05.002

Certain bacterial species and their metabolic products, particularly short-chain fatty acids like butyrate and propionate, may stimulate L-cell secretion

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