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One study found that mice treated with 5-Amino-1MQ had significantly lower body weight, smaller fat cells, and less overall fat mass than untreated mice , despite no difference in food intake
High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance
Repeated oral exposure or consumption of larger volumes (above 10mL) can cause cumulative mucosal damage, gastritis, and in severe cases, metabolic acidosis particularly in individuals with compromised hepatic function
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