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The mice were maintained on the same diet used to induce DIO by Jackson Lab, 60 kcal% from high-fat diet (D12492i, Research Diets Inc., New Brunswick, NJ, USA) with ad libitum access and sterile water was provided from the Lixit System
Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death
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The main GLP-1 tablet for weight loss is Wegovy tablets, which contain semaglutide