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Leucine is the most abundant amino acid in proteins (Duan et al., 2016) and is usually administered orally or intravenously as a nutritional supplement to increase protein synthesis and maintain energy homeostasis for repairing muscle injuries

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49 Elevated inflammatory factors in T2D such as IL-6 and interferon- (IFN-) cand bind to their receptors, activate JAK2/STAT3, subsequently upregulates the expression of suppressor of cytokine signaling 3 (SOCS3), which inhibit IRS-1 cascade

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[DOI] [PMC free article] [PubMed] [Google Scholar] Wang M., Ma X., Zong S., Su Y., Su R., Zhang H., et al

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