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In agreement with our immunoblotting analysis, we observed an induction of CHAC1 under cystine starvation in CHAC1 expressing H1299 cells but not those subject to CRISPR/Cas9-mediated CHAC1 knockout 48 , indicating antibody specificity (Supplementary Fig

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Figure 1 The melanocortin receptors are modulated by several endogenous peptides, such as -, -, and -melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), which are derived from proopiomelanocortin (POMC) precursors (29)