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In addition to direct effects on ion channels, neurotransmitters may bind to G-protein coupled receptors, thereby eliciting cell-signaling effects that could result in metabolic changes (e.g., alterations in activity of various enzymes) within a postsynaptic cell (14)

The SURMOUNT-4 trial demonstrated that patients who discontinued tirzepatide after achieving weight loss regained significant weight compared to those who continued treatment, though not all weight loss was reversed during the study period

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Bile acids may stimulate insulin secretion via activation of FXR and inhibition of ATP-dependent K + channels (172)

125 Valproic acid causes minimal cognitive impairment