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[5] [6] Extensive post-marketing surveillance and clinical trials have not established a causal relationship in humans using these medications

doi: 10.1080/10408398.2022.2119204 95 JankunJWyganowska-witkowskaMDettlaffKJeliskaASurdackaAWtrbska-wietlikowskaDet al

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The clinical success of dual and triple incretin agonists has validated the concept that engaging multiple complementary pathways within a single molecular framework can yield superior efficacy without proportionally increasing toxicity ( 3.3 Improved tools for mechanistic validation and risk de-risking Technological advances have also improved the ability to de-risk peptide systems earlier in development

No stomach contents that might cause nausea when combined with a GLP-1 agonist