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The following applies: Even though overdoses rarely have critical consequences, you should always use high doses with caution and have your blood levels checked regularly if you are unsure

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doi: 10.1016/j.jpsychires.2021.02.053

Hippocampus 29(2):7377 Buck SA, Baratta AM, Pocivavsek A (2020) Exposure to elevated embryonic kynurenine in rats: sex-dependent learning and memory impairments in adult offspring

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This is particularly concerning for older adults, postmenopausal women, and anyone with existing osteoporosis risk factors