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This dominance reflects semaglutide's established and expanding role in the clinical management of type 2 diabetes mellitus, where it is approved as a monotherapy and combination therapy option demonstrating superior glycated hemoglobin (HbA1c) reduction of 1.5% to 1.9% from baseline in pivotal SUSTAIN and PIONEER trial programs

Cosmetic medicine must consider authorisation, manufacturing quality, patient selection, long-term monitoring and whether the expected benefit justifies the risk

11 The SELECT trial showed a 20% reduction in the risk of these events in adults with obesity and cardiovascular disease but no prior history of diabetes

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