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doi: 10.1016/j.neubiorev.2020.02.002

Furthermore, pharmacokinetic heterogeneity across patient populations, driven by genetic polymorphisms in metabolic enzymes or variable tumor microenvironment conditions, necessitates personalized dosing strategies yet remains underexplored in clinical settings [164]

doi:10.1186/1471-244X-12-221

Cross-linking mass spectrometry combined with integrative structural modeling mapped this ensemble at near-atomic resolution, revealing conformational states that differ substantially from the static structures captured by cryo-EM alone (Zhang et al., 2023)

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Tien, J., Truslow, J