A Personalized & Compassionate Approach To Weight Loss & Weight Management
The GLP-1 pathway GLP-1 is secreted primarily by endocrine cells in the small intestine and proximal colon in response to nutrient ingestion
10.1038/s41467-020-14934-5 87 WuZ.HuangZ.SunL.FuY.ChenS.WuS.et al (2024)
6 Second Nature's Mounjaro and Wegovy programmes Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes
As a triple incretin receptor agonist, it: Activates GLP-1 receptors , reducing appetite, slowing gastric emptying, and improving insulin secretion Activates GIP receptors , enhancing insulin response and potentially supporting fat metabolism Activates glucagon receptors , increasing energy expenditure and hepatic glucose output Whilst glucagon receptor activation increases hepatic glucose output, the net glycaemic effect of retatrutide is mitigated by the concurrent GLP-1 and GIP activity, resulting in overall improvements in glycaemic control in trial participants
Semaglutide is administered as a once-weekly subcutaneous injection using a small, fine-needle pen device that is simple and virtually painless to use at home
