et al., 2007) and prevents cell death due to the protective function of SIRT3 (Hafner et al., 2010), which stimulates SOD, responsible for enhancing the detoxification of ROS (Chen et al., 2011) (Figure 2)
Indeed, biguanides including phenformin showed clinical benefit in diabetic influenza patients and hence the compound was suggested as a COVID treatment option 65
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Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin
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