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Saunders takes a similarly cautious strategy with her patients: When our patients are off medication for an extended period, we generally recommend starting back at the lowest dose and titrating up gradually. The more doses a person has missed, the more likely they are to have difficulty tolerating the medication when they restart it, and the more likely they are to have gastrointestinal side effects, Low Wang says

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54 The group on tirzepatide had an average weight loss of 20% bodyweight, which was sustained over the 3-years

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Medication adherence is crucial

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