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Vitamin B6 in its less common form of pyridoxal 5-phosphate (PLP) may be less likely to cause neuropathy at high doses

Most patients begin at 2.5 mg weekly, then increase by 2.5 mg every four weeks until reaching their target maintenance dose (typically 5 mg to 15 mg weekly)

Clinical trials have provided compelling evidence for their benefits, although the results reveal some differences in their potential impact

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Injections require a small needle (similar to insulin delivery) once weekly, and many patients find this schedule simpler than managing daily pills

Research has demonstrated that obesity is associated with increased risk of type 2 diabetes, heart disease, stroke, sleep apnea, hypertension, and certain cancers