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B12 may also support mood regulation, reducing feelings of stress and anxiety

This increased glutathione pool may help contend with the increased flow of free radicals from dysfunctional mitochondria

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High dose vitamin C is generally synergistic with glutathione (vitamin C actually recycles oxidized glutathione back to its active form), but mega doses above 2,000 mg taken at the same moment as oral glutathione can compete for absorption in the gut