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Frontiers in Endocrinology, 2026

Published 2017 Feb 15

10.1016/j.tiv.2012.01.013 Toxicol

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The reasoning strongly suggests no clinically significant pharmacokinetic interaction, but pharmacodynamic nuances related to GH-axis stimulation remain incompletely characterized

This process disrupts the electrostatic interactions between histones and DNA, thereby leading to chromatin decondensation and the generation of reticular structures with diameters ranging from 10 to 100 nm [99, 100]