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Routys study showed that after the use of antibiotics, intestinal Akkermansiamuciniphila bacteria decreased, leading to a reduction in the effect of immunotherapy (Routy et al., 2018)

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The Bioavailability Evidence For decades, the standard assumption was that oral glutathione is broken down into its constituent amino acids in the gut before it can be absorbed intact, making supplementation ineffective at raising cellular GSH levels

Further, KD should not be used in patients with chronic kidney disease, liver failure, hypertriglyceridemia-induced acute pancreatitis, heart failure, especially NYHA Class IV, eating disorders, respiratory failure, as well as in the elderly, and during pregnancy and lactation ( KD is widely used as an adjuvant therapy for many diseases

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