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A DXA substudy of 160 participants from SURMOUNT-1 found that pooled tirzepatide doses reduced body weight, fat mass, and lean mass all significantly more than placebo, while the proportion of weight lost as fat versus lean mass stayed similar across age and sex subgroups

This combination of effectiveness and safety is accelerating their adoption across both diabetic and non-diabetic obese populations

Pharmacology Tirzepatide is a once-weekly GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist that integrates the actions of both incretins into a single novel molecule

The interactions between oral-gut axis microbiota and Helicobacter pylori [J]

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