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It is worth noting that, although the downstream targets of FTO have been researched as mentioned above, studies on the upstream subject of FTO remain deficient
For instance, conditions such as anal fissures, rectal prolapse, or even colorectal cancer can mimic the symptoms of hemorrhoids
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363 Furthermore, icariin has been found to inhibit ferroptosis in synovial cells and exert a protective effect through activation of the Xc /GPX4 axis
The combination of immunotherapy with biologic agents, including anti-IgE, anti-IL4, and anti-IL13 antibodies, may further enhance both safety and efficacy, particularly in patients with multiple allergies
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