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Nevertheless, detailed functional analyses of these receptors may offer valuable insights into the fundamental mechanisms governing glutamate-NO-Ca 2+ signalling and could ultimately aid in identifying novel therapeutic targets

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Carbonyl cyanide m-chlorophenyl hydrazine renders the inner mitochondrial membrane permeable to H+, leading to membrane potential destabilisation on both sides of the inner mitochondrial membrane, and then, via the Pink1-Parkin pathway, which is specific for membrane potential destabilisation, the mitochondria undergo further membrane potential (MMP) hyperpolarisation, which generates ROS

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