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Weight loss was greater in female participants (up to 30.8%) than male participants (23.2%) at 80 weeks, a sex difference consistent with Phase 2 findings according to Dr

Funding: No external funding was received for this study

180 , 519530 (2012) Scheres, S

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This interaction underscores a broader metabolic complementarity: while GLP-1 RAs primarily drive weight loss through appetite suppression, delayed gastric emptying, and insulinotropic effects, microbiota-targeted interventions may act on additional pathways involved in energy expenditure, substrate utilization, and muscle preservation, thereby potentially reducing inter-individual variability in therapeutic outcomes

Therapy with ingested immunomodulatory proteins