PlexusDx Precision Peptide Genetic Test ($99 add-on after first month) analyzes variants in GLP1R, GIPR, FTO, and MC4R genes that influence appetite regulation and metabolic response
In recent years, a variety of mechanisms for the beneficial effects of GLP-1RAs on the brain have been discovered, including the reduction of neuroinflammation and increase of signal transduction in surviving cells
The mild elevation of -BB, coupled with a conserved amino acid change, suggests that D72G is a hypomorphic, milder variant resulting in a quantifiable metabolic phenotype where small deviations in -BB levels are metabolically tolerable in C
One participant had not had an HbA 1c measurement at follow-up
Initial studies have confirmed its safety and efficacy in a small cohort of patients with immune-mediated DED (Watane et al., 2022)
A court decision on this could come by the end of 2025