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J Neurosci 4(7):18841891 Saransaari P, Oja SS (1995) Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain

10.1164/rccm.200811-1757ST

FIN56, an inducer of ferroptosis derived from CIL56, promotes endogenous antioxidant activity by either facilitating the degradation of GPX4 or binding to and activating squalene synthase (SQS), which results in the depletion of CoQ 10 [135]

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Identification of the exact mechanism for the lethal effect of silencing the enzyme requires further experiments, as do the effects of inhibitors, which are not necessarily solely due to loss of enzyme activity, because the inhibited enzyme may also have a gain of function leading to cell death [72]