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The TKT gene is located on chromosome 3p21.1 and is composed of 15 exons that generate three alternatively spliced mRNAs that collectively encode two distinct protein isoforms

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However, it is critical to emphasize that the clinical data included in this meta-analysis do not directly demonstrate activation or inhibition of these pathways at the tissue or molecular level

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Related Reading: For a comprehensive overview of IGF-1 LR3 research, mechanisms, UK sourcing, and safety data, see our IGF-1 LR3 UK: Complete Research Guide (2026).

The CONSORT diagram is presented in Fig