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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Darmaun D., Smith S.D., Sweeten S., Sager B.K., Welch S., Mauras N

After 2 weeks of treatment, mice treated with GLP-1MK-801, as well as those subjected to calorie restriction or GLP-1 monotherapy, demonstrated enhanced glucose tolerance compared with mice that were treated with the vehicle or MK-801 monotherapy (Extended Data Fig

Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

Some individuals may also experience digestive discomfort at higher intake levels

2.8 Data analysis The data were presented as the means SD or means SEM

doi: 10.3390/antiox11091679