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Phase 2 trial data showed remarkable results, with participants losing up to 24% of body weight over 48 weeks at the highest dose

Catabolism of -Amino--Carboxymuconate--Semialdehyde: ACMS The -amino--carboxymuconate--semialdehyde (ACMS: 2-amino-3-carboxymuconate-6-semialdehyde) product of the HAAO catalyzed reaction is ultimately catabolized to acetoacetyl-CoA

On the other hand, in vitro experiments demonstrated that GLP-1RA morroniside could act directly on primary microglia, and promote the mRNA levels of the M2 microglial cell markers Agr1, C206, IL-4, and IL-10

Batta A, Hatwal J