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Cagrilintide No - amyloid fibril risk Retatrutide No - standard peptide handling State Light protection Cagrilintide Yes Retatrutide Yes State Oral viable Cagrilintide No Retatrutide No Both compounds share similar refrigerator windows

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For comparison, this ratio is 2.5 (Koh et al., 1995

We used both MR-PRESSO and Q-statistics to identify outlying SNPs and looked for evidence of significance in Weighted Median, MR-Egger and contamination mixture-based estimates pre- and post-Q-based outlier correction