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Hepatocellular damage from inflammation, necrosis, or advanced fibrosis can release stored B12 into circulation

Safety and Metabolism of Long-term Administration of NIAGEN in Healthy Overweight Adults

For comparative purposes, rate constants are also shown for ascorbate and other metabolites

Xiao M, Xu J, Wang W, Zhang B, Liu J, Li J, et al

6-Month Cycle: Inject 1mL per week of month 1, every other week in month 2, 1 time per month for months 3-6 (10 ML total)

Among these, coumarin and L-leucine showed the highest test statistics and lowest p-values, indicating stronger group separation relative to other metabolites, while L-octanoylcarnitine and kaempferol exhibited more moderate but consistent differences