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This interaction between genotype and selenium was also verified in cardiomyocytes where selenium was found to have a diminished effect on stimulating the expression of the Leu variant (216)

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Folate tolerance varies Folic acid, folinic acid and methylfolate may help selected patients but may worsen anxiety, agitation or sleep in susceptible undermethylators

Or give you other reasons for fatigue If you come on this forum regularly , you will realise that more or less all of us are forced to self -inject B12 because we cant get injections regularly enough to keep symptoms at bay

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