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NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer

A more recent structure of a high affinity ( K d 100 nM) 1:1 complex between MeaB and the Cbl-binding domain of an MCM, solved in the presence of GMPPCP, reveals a completely different dimer conformation, where the two nucleotides are now quite close to one another, sandwiched at the dimer interface, with the switch III loop now engaged in direct interactions with the nucleotide of the opposite protomer of MeaB, effectively burying the bound GTP (Figure 43B)

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Although the procedure itself is straightforward, attention to detailsuch as using sterile supplies, selecting an appropriate diluent, adding BAC water slowly, minimizing unnecessary agitation, and storing the finished solution correctlycan help preserve peptide quality throughout the course of a study

2023Mar;1(194):114724

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