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doi: 10.1371/journal.pone.0158205 232 ChenSSunJZhaoGGuoAChenYFuRet al

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The SELECT trial enrolled over 17,000 patients with established cardiovascular disease and demonstrated a 20% reduction in major adverse cardiovascular events

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Given that NSAIDs inhibit Cox activity and Cox-2 is expressed in activated B lymphocytes and is required for optimal antibody production, it is pertinent to predict that NSAID therapy can have repercussions on antibody synthesis