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To further precision oncology, this review provides a thorough understanding of TDMs potential to improve treatment outcomes and reduce side effects in cancer patients (Fig
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10.3389/fendo.2019.00480 Front
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Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)
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