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Prill S, Caddeo A, Baselli G, Jamialahmadi O, Dongiovanni P, Rametta R, et al

Why Your Hands and Feet Feel Cold First When the body feels it needs to conserve heat or energy, it practices a process called peripheral vasoconstriction

The World Health Organization estimates that 17.9 million people live with CVDs each year, and CVD-related deaths accounted for 32% of all global deaths in 2019

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Noteworthy, SGLT2-i have been shown to interfere with sodium-hydrogen exchanger (NHE-3), which is primarily responsible for sodium tubular reuptake following filtration and is markedly increased in heart failure (HF) (42)

See Important Safety Information about GLP-1 medications, including Boxed Warning, at ro.co/safety-info/glp1 Contact: [email protected] SOURCE Ro