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To enhance the precision of targeted siRNA delivery, Pi et al., enhanced EV-mediated siRNA delivery by incorporating folate and RNA aptamers as targeting ligands, which specifically bind to receptors overexpressed on cancer cells

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A 5.0 L aliquot of sample was injected, and separation was achieved using a binary solvent system consisting of (A) 0.01% (v/v) formic acid in water and (B) acetonitrile (ACN)