As one of the most conserved structures in Gram-negative bacteria, LPS is recognized by the host to initiate potent immune responses against bacterial invasion
Med ., 11 (3), e372
Moreover, mice with neutrophil-specific Gpx4 haploinsufficiency develop lupus phenotype and inhibition of neutrophil ferroptosis significantly mitigates disease development in lupus-prone mice
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Overall, these results suggest that oral GSH supplementation can effectively increase body stores of GSH and may also reduce oxidative stress and enhance certain aspects of immune function, particularly NK cell cytotoxicity
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