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Acknowledgements We thank all researchers and clinicians for their contributions to the field and apologize to those whose work we did not describe or cite

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Patients frequently report nausea, diarrhea, vomiting, constipation, and abdominal pain, particularly when initiating treatment or increasing the dosage

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Most ED patients can tolerate the side effect when injected with the correct dosage for PT 141 or even when they inhale