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However, exposure to a cholesterol-rich TME, as exemplified in SQLE-high HCC, causes mitochondrial dysfunction and accelerates exhaustion in CD8 + T cells [157], while cholesterol precursors, such as lanosterol [159] impede the mevalonate pathway in CD8 T cells, hindering TCR signaling
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Researchers employ this compound to analyze peptide stability, receptor binding, and molecular pathways under controlled laboratory conditions
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doi: 10.1016/j.micpath.2018.04.036
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