semaglutide compound vs wegovy Compounded Wegovy: Is It the Same Drug? Concerns Surrounding Compounded GLP-1s Mount

Journal Diabetes Research

Because it stimulates the bodys own growth hormone production, dosing needs to stay within physiologic limits to avoid excess IGF-1. If levels climb too high, she notes, you might get symptoms such as fluid retention, joint stiffness, carpal tunnellike numbness, or mild insulin resistance, though these effects are uncommon with conservative dosing and regular monitoring

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2025 Nov 27:S1534-5807(25)00690-2

The jump from 1mg to 4mg produced nearly double the weight loss, from 8.7% to 17.1%, suggesting that the glucagon component only becomes meaningfully active somewhere in that dose range

Cognitive health